Study: Low dose aspirin may not cut stroke risk

NEW DELHI: Taking low dose aspirin, a blood thinning medication, each day is probably not as helpful for main prevention of stroke within the aged as believed earlier.

It will probably, then again, enhance the chance of bleeding inside the mind tissue, a brand new research revealed in JAMA Community Open – a medical journal revealed by the American Medical Affiliation (JAMA) has revealed.
On this research, researchers recruited 19,114 aged individuals of whom 9,525 obtained aspirin and 9,589 obtained placebo. After a follow-up of 4.7 years, on common, they discovered that there wasn’t any important discount in ischemic stroke, additionally known as clot-related stroke, between the 2 teams. Nevertheless, the researchers discovered a statistically important 38% enhance in intracranial bleeding (bleeding inside the mind tissue) ensuing from a mixture of haemorrhagic stroke (mind harm brought on by bleeding within the mind) and different causes of intracranial haemorrhage amongst people randomised to aspirin.

Dr MV Padma Srivastava, professor and head of neurology at AIIMS, advised TOI that the JAMA research reiterates what consultants have been saying for lengthy. “You can’t prescribe low dose aspirin indiscriminately to forestall stroke. It is very important analyse the dangers versus the advantages, particularly among the many aged individuals who’re prone to head harm from falls. It will probably result in excessing bleeding and demise,” she stated.
Dr JD Mukherji, vice chairman and head of neurology at Max healthcare additionally stated aspirin is a cornerstone of antiplatelet remedy for the secondary prevention of stroke and heart problems, however its function in main prevention stays to be ascertained. “Dependable strategies for quantifying platelet exercise, for instance gentle transmission aggregometry, needs to be thought-about to determine people at elevated cardiovascular danger,” he stated.
Aspirin is an antiplatelet agent that has been utilized in low doses (75-100 mg/d) for the prevention of cardiovascular occasions. Its main opposed impact is an elevated bleeding tendency. In response to the JAMA research, the medication continues to be extensively used for main and secondary prevention of stroke regardless of some current unfavourable findings.
“The principal discovering of this secondary evaluation of a randomised medical trial was a rise in intracerebral hemorrhagic occasions, which in absolute phrases outweighed a smaller and non-significant discount in ischemic strokes,” researchers have concluded within the JAMA research.

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